Tubers, epileptogenic foci, and epileptogenic networks in tuberous sclerosis
نویسندگان
چکیده
منابع مشابه
Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex.
Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the...
متن کاملLocalization of the Epileptogenic Foci in Tuberous Sclerosis Complex: A Pediatric Case Report
Tuberous sclerosis complex (TSC) is a rare disorder of tissue growth and differentiation, characterized by benign hamartomas in the brain and other organs. Up to 90% of TSC patients develop epilepsy and 50% become medically intractable requiring resective surgery. The surgical outcome of TSC patients depends on the accurate identification of the epileptogenic zone consisting of tubers and the s...
متن کاملImaging epileptogenic tubers in children with tuberous sclerosis complex using alpha-[11C]methyl-L-tryptophan positron emission tomography.
Several reports have indicated that cortical resection is effective in alleviating intractable epilepsy in children with tuberous sclerosis complex (TSC). Because of the multitude of cortical lesions, however, identifying the epileptogenic tuber(s) is difficult and often requires invasive intracranial electroencephalographic (EEG) monitoring. As increased concentrations of serotonin and seroton...
متن کامل"Epilepsy surgery recipes galore": in quest for the epileptogenic tuber in tuberous sclerosis complex.
Tuberous sclerosis complex (TSC) is a genetic disease, the life-long neurological morbidity of which is usually defined early in life, by epilepsy and cognitive delay that typically go hand in hand. Early onset of epilepsy is the one of the important risk factor for continuing seizures and cognitive disability later in life (Curatolo et al. 2008). Early and aggressive treatment of epilepsy is, ...
متن کاملTuber or Not Tuber: The Question of Epileptogenic Lesions in Tuberous Sclerosis Complex (TSC).
Commentary In any form of epilepsy associated with distinct anatomical le-sions within the brain, questions arise as to whether the lesional tissue alone is epileptogenic, whether perilesional cortex is also epileptogenic, or whether even more remote cortical regions that appear structurally normal may serve as independent epileptic foci. In disorders associated with multiple distinct lesions, ...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2010
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2010.02713.x